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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b7db4a73e1f2dfc3a4338b7c74bf5c646f961af940793eb179a96385995663' 
  AND token = 'Kkncn5S5wkSYeAFw26zzH5IanCMOSgHParCY6RLB6Ro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}