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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e50994b2d75e67624049429bc5553d7982960d01527157fe8e5038abaa667c' 
  AND token = '6Ow4FRmdyeRiKYjBANmHLcVKf9dKOZwFJnDR3R2K9DE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}