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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5749e1c2b5dae2d63a945b95beec17ee5bfd6b12e4406dee3bac037e22d8ce88' 
  AND token = 'jpbTNE6IelBy9W4YaXmk6AskixZiKCLDU0TKgRkjjeE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}