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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10f21cb4e4b0afbf6fa03d91537b7229a0c41a9f8589f31b2fa69017ae768004' 
  AND token = '1/EKw0utIU5qH9K7ZkjolPatLhxHc7d6ROgJHJBhuXA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}