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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c52fbd6b3dc1782f2a384f9ceef6c087dddb653c4e206404665404ee9842f99' 
  AND token = 'FMdYdJgNOG/6X1qLJeCrfY5iRPE3LpyXQn3JxSH8v1I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}