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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7553a2099b3bd42904ed5b3cdde50d533d2cf586a2bd8e9f8442476c5600b76f' 
  AND token = 'upZh+G8MN+ZCmIYZFIIoT8AwhfZytF87o3A5YcHbNcI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}