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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b780642eac15768d72dc80e4bf30b1db7ecb3f1c6f409814e59bc1e4f2e166c' 
  AND token = 'IoJlxGcKrIN3V/hpsX+7yybVQO7SE7bXxdGRtUseq/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00062

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}