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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b22f12089ebb291c8059ea9bb2ca4cfae31c6a0ef730dbec892493f9cbe287d' 
  AND token = 'e5uMwFLG7CwdaqGqgqgL1sA+WDYLbncCTsLEYOP8OxU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}