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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649e5d00b0887cc6cc27683d37beeb0f63bd0fefa8f23199d039ec69f36c3f90' 
  AND token = 'GvAheAqDUc3bra26BLKLRZL9QhHfjc+WN0KMs8cw3Aw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}