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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250835199a5eb67771b067b91f9972b4dee8d1279906904e586da13e1cb227c3' 
  AND token = 'De8DjtjR3Ic1vU1LJ9luSrjFmxrkrXisZ07OjLLdI7k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}