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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5997c22cbb8750d6c0dbd9614a270670b22873c7538b23b465b075ef85fd8da7' 
  AND token = 'SkBP3NN4Sv/tSeKB8RotP9AkLvXz+GVTiCWsxQxsHqs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}