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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f95315cf4cc119b5d8ce421590cd4bf7e6dd86f6e4116765099d00bd1386917b' 
  AND token = 'VdPsJK2DtmwGBn0s8gu8OtMBspkJmbqILOGWUrq9wwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}