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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4dfbaf07ea300fc94ceccc5a39efd16296e82a1456c36a9aab4366e95b6f34d' 
  AND token = 'JEO0qux7EdCPoyWoW97D+FJ96tnNfP4iczzKLgYFwJ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}