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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0b8d6fc76f5450f23c812236773e183cc1ee57a1e81a154af40ac9c4afbdbf4' 
  AND token = 'E1+INNeScVuT2jKEOXEa+A5vH2fsbqOQ8KDfIygfoW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}