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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ade1f461415c1a29964f3016f59bde3c2b09d4e95679e1152de97a8bae00e6d4' 
  AND token = 'ZRx5BoRtE4Ds5u8Hk+kXIp6ypYS0OSNXWdB8JdXjWyQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}