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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57a5d78e5a53c4bbea90082c1fc0c2fecb390eb53b91bc15a66a5d64499b566d' 
  AND token = 'zuMWOdMH30SbYD0S4i5otZjSgHzM0OQeFgbKGuwYMSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}