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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14e3919bf87bf4a60b4e30d6c563c327fde7e2aee77dde7ac37d978d785779cb' 
  AND token = '7IGp+467B8yYXjXpFhxa2eXYs4PzHNg5XnS11v9cf14=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}