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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c415c22f18b4cb0e34851f08bebae3b4bebf08813a7c04e2fc0d61d04057015' 
  AND token = 'iRlMIJSMrxGf0tozRhW3ZAbBCIfmW+VPQCR8GQDwRo8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}