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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ddf1112d2c92f48f646a5e06f4c5e2d8c95f3c7a147848bee6642d16199c07f' 
  AND token = 'JxjDWul0fdn0ddR6f5TAVMasz505btDZ3XNfeqF+qVw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}