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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5221d57e4de9203645abfc09f38061f8c8604dc5c9d5f1fd55ab0ba4e23e1a84' 
  AND token = 'w+F+oKTSTTeBB6qMlwv0LSAqLBzVU4vDbwFULN66ObA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}