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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af735299c58fdfd79ef01e2b8db6e9e01f324129c84ffde5a22e0232e48d29ca' 
  AND token = 'TSdZPTMm6hq/5PEkZRTrkF66p1EvXpQzuP6PP2200jQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}