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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49ff9112a51cb96d35dedd38870536979927e30f3ed3187f72be8bf50b2f3372' 
  AND token = 'jOUvAtkPSqudAKBVMLybkbHb3E5alko5IQg1p7st3Bw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}