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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8181014526b2dd3ee18b92f272d134a1e1c41bd6fcc195fc9f379b0e1ebce601' 
  AND token = 'CR+GKNJPgg+CyrEtDVcCrKfWEBKpzvFoua5FWl+BoaY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}