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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543c6dd6f084df333d581226d72a900f9a785c21ba76368c3892d62258248667' 
  AND token = 'IH5i7ihsOXTDwHdGUwtO7442nazv2hw4kLPLHu1MREo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}