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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '521adbb98791d2c8d680c87741b79f8764954b12723d83dd8b6f03a8ef3b2314' 
  AND token = 'OeTiDlou+VOIHZAW/jlM9WDi3YEpzF3XUcSbZw4Rec0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}