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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef0ff76797207d4cf2d6abdfd93b72f7c173da25cd1dc5bdd0cff5c8c1db01c0' 
  AND token = 'WqI8125a0j6XT+3yksRllP2rYw109crnCYK1HxyCYfc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}