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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ed35c19de3855378360f06d2c2347be4f868b6adc9ffe1a5bd7773681c04a69' 
  AND token = '3UAK1gbG9y0AAX6R9vC3K67pZp8793eSnDkWOeO+9cs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}