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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d2a373b737a1748ad2b1e61095471d8a6bde03801dc3c137510d33b8d0c8ad4' 
  AND token = 'qd6ctFQ0Kp/b5xy4g+vs8NuF0Hkscpf0PRQPSGsugLE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}