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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43b2ed73407c2e7305b4da0765e41bb9ac96d829cf21fb26772a3d02740a3f59' 
  AND token = 'k493DCrdU6srZyFAMIvlju67zhL4r7pIEJxEM219xvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}