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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50a6810ab84a2a6d9be74ca23f33a4fc84c999025a1ee715f0e3a20536507480' 
  AND token = 'iPHDGjSh5fSG9ZKySzhWnz+0fN17K5bldBvvGDwOwaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}