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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3dc01f3caca9b7b1e2c014e09f7a0fbf8e03a578d661f805d9beb278c0bfa656' 
  AND token = 'keI5rmYpfRasXioe7xwAT1DE+qG0lxiUcjgDfAM8dGs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}