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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'be6be1f8bb341fe733e6308303caa06329d1a0a07406a057d22c214735f9178d' 
  AND token = 'f2hCM2ce+M6PCk/FZntEDqwr/8HN8+U1/GfZ/BaSZp8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}