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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dd18025864186277232453ebd6caa9859dfda231f1e54cc083ec9328818b6820' 
  AND token = 'NVXHMN8C9oa1GRZrTzXXTyGmVOvAePENtc2gR6GJ1sI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}