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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e021654d94c4a21f49094fda333b6c8b6bfb188ca7da134b47e04412f80eaec0' 
  AND token = 'jJubktxZw56XQnnUdrBrUmF62FWyu3KJNNkJsh1t4mk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}