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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '121a2d56947a0fd76b1bc4afa960d99de45f8e3b08ed4cba69f00b904d6dfcee' 
  AND token = 'KmA27yTWbUB6zPIlE+u/C3Akykiid6MZ0UiOZEVtAiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}