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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b7f4e12991cdd367f0c9cf300c5568afea228fd0cdecfb27cc91ec1fa49beb3f' 
  AND token = 'ls2CcgKL2Mii/KSN+zrX5hEumTsaGtWJslw2kOEiMLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}