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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '243b270756d92ba69c13f2c493b06d1f7c0cf1e24b9b0cc5c53bb8a9e0801fbb' 
  AND token = '4hWH8wUkrD08gV9WO3+nZRhra502mqdfQP7S6S6dEmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}