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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b1f000a78ed71801216818b9bfa1f6afdc60b708f77fe29f64e3c1edffb426d9' 
  AND token = '9/q6sp8IoeZsL/bp1156oeZiexaU5pmJKykO+xgx6Ig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}