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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8601e17f6cc16d48f7dbd1027edc5d8a257f6425610d2de5959b2fd1c5e9060b' 
  AND token = '8DdcDInrfJQQvL1ZjMaC7m3I8SBrl0c7f6Kwp5YwgGY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}