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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f44f9f76d9003e530f833727e6c4fa47f15054c3de2dfe4e1156c4dccc0de07b' 
  AND token = 'm351+ezz60LR8zkwiCfCkJGYvEcyi54lPu5aHGpCm34=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}