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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '539c975a69fdf2ffc0be11d2aa8f7f4c258cc329a3a0cc25973655e265a621c9' 
  AND token = 'ZtHRVCGz5i4lVXGJ8VeHokfrOddmxbfnFNr+NzE6E6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}