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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ee161b60de5242ba9e8369aebfce1d0404a2d52c7eb4229aba328a6517422604' 
  AND token = 'AdPVGC/GDc/Q2BDDs+Xn9m3glIEFN4zBt80aoqihEe0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}