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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65f09fb8c462152c5d5aa8db7189182b56aaf86d44f4005c4450d46f7ccabe89' 
  AND token = 'hYSJ8fahw/jcw+h7un1RGYdwTDeztFEEMbeUvy7n0K0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}