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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80f8462bf7f5a05cbb2568db09d27ac3996183bfc8ef4548c4a8a293e7a385cd' 
  AND token = '2l8+58LgscLHjuOpOuSMSDh7FZs2A6c1161ZDvZiXhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}