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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44244562c706540227e52478f96bcf54edf32ffc4423f4d08ee76c875e8a1343' 
  AND token = 'Bk3SsiYYrfbdmMJHBR2962gtQHshZ+84RDjQiwzyOmI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}