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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53b83e182c6287053302e9af467bd42a7e5b7a36a70c1e941a7032b51bfd39d2' 
  AND token = 'PKTkV4VJ26fekrFZDA0W6DMjErCGEJFOO4OPSjG/hW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}