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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed104072a457e1c2678775e9c64b02727b8658a9aac0fa69195ec1c85666158b' 
  AND token = 'tKziypBapg1tOFElj34isFkwyftqh2PCuZPl79jKBKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}