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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a749b314b8685ecdba117a5bea75fa27a0b6006c2fe06693fef5e199fdad0be7' 
  AND token = 'VZ3XWWC3ZfMzhVSh9+La1QGjZDRMx27X+LBoPIq0Enk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}