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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b50f674e473b6fa660c03ecf387abce5026f96362ef7f2cbf5e0796264d82e1' 
  AND token = 'IFVf7yJUZu6vuZIeT3CCS18kW/ZvBzhfK3GXDgSGtt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}