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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e22fc370d88ae001b0c9b6d06c4846efe7cdbf25c3f672d3db75d2063fce878' 
  AND token = 'bLpH9KIJqRHOFLAYp9G4DLGaEk+KaGhPwEo1aW4ZtFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}